For medical use of preparation
Active substance: іsoxsuprinehydrochloride;
1 tablet contains іsoxsuprinehydrochloride 10 mg;
Additional ingredients: microcrystalline cellulose, sodium crosscarmellose, magnesium stearate, colloidal silicon dioxide.
Medicine Form. Tablets.
General physic-chemical properties:white circular flat uncoated tablets scored on one side.
Peripheral vasodilator. Derivative of 2-amino-1-phenylethanol. ATC code C04A A01.
Isoxsuprine - is a peripheral vasodilator, the beta-adrenoreceptors agonist. Due to stimulating influence on beta-adrenoreceptor іsoxsuprine, it decreases tonus of smooth muscle of blood vessel, eliminates their spasms, improves peripheral and cerebral circulation, and tissue blood supply, respectively. It has positive inotropic and chronotropic cardial effect and tocolytic effect. During in vitro and in vivo studies, іsoxsuprine inhibited spontaneous and oxytocin-induced uterus activity in aborning.
Isoxsuprine has also minor broncholytic action. In large doses it inhibits platelet aggregation and decreases blood viscosity.
Isoxsuprine is easily absorbed from gastrointestinal tract. It is metabolized by partial conjugation in liver. In oral usage, maximal plasma concentration is reached approximately within 1 hour. Half-life period is approximately 1.25 hours. It is excreted mainly with urine, and slightly – with faeces.
The peripheric circulation disorders of different genesis: obliterating endarteritis, limb artery atherosclerosis, diabetic angiopathy, Raynaud’s disease and syndrome,
Chronic cerebrovascular insufficiency of atherosclerotic genesis,
Atherosclerosis of retinal arteries.
Hypersensitivity to the active substance or to any other ingredients of the preparation.
Bleeding and hemorrhage in history.
Contraindicated use of the drug immediately after birth..
Do not exceed the dosage and duration of the treatment, prescribed by doctor. In case of any unusual reactions occurrence, within the preparation treatment, it is necessary to consult the doctor.
Drug interactions and other types of interaction:
There is no data concerning negative interaction of іsoxsuprine with other medications.
It is possible enhancement of vasodilatory action in concurrent usage with vasodilators, which are used in cardiology.
Peculiarities in usage:
It is necessary to administer the preparation with caution in stenocardia, tachycardia, flushes, blood coagulation disorders, glaucoma, acute phase of myocardial infarction and insult.
During treatment with the preparation, elderly patients should get up with caution and avoid sharp variation of body position to prevent orthostatic hypotension.
The preparation effect can be decreased in smoking patients.
It is necessary not to consume alcohol during treatment with the preparation.
Because of the risk of pulmonary edema in the mother and fetal tachycardia should not use the drug Suprilax ® during preterm labor and delivery complicated by infection.
Pregnancy and lactation.
Administration of Suprelax® to pregnant women is contraindicated. There is no data concerning the safety of іsoxsuprine administration during lactation period, so it is necessary to avoid the preparation usage during lactation period.
Influence on velocity reactions while driving motor transport and operating other machines.
The preparation can cause somnolence and dizziness. In such case, it is necessary to avoid driving auto and operating other machines.
Administration and dosage.
In diseases, which are accompanied by blood circulation disorders, the preparation is administrated as 10–20 mg 3–4 times per day after meal. The treatment is 2–3 months.
There is no data concerning the preparation usage in children, so the use of Suprelax® to children up to 18 is contraindicated.
Symptoms: Tachycardia, palpitation, chest pain, arterial pressure reduction (collapse), dizziness, weakness, loss of consciousness, nausea and vomiting.
From cardiovascular system: tachycardia, palpitation, arterial hypotension, chest pain.
From nervous system: dizziness.
From digestive apparatus: dyspepsia, nausea, vomiting.
From skin and subcutaneous tissue: skin rash.
Systemic condition and disorders, associated with the route of drug administration: weakness, flush sensation.
Immune system: people with individual intolerance to any component of the drug hypersensitivity reactions are possible.
Keep it at the temperature not more than 25 oC.
Keep it out of reach of children
10 tablets are in a blister or strip, 1 or 3 blisters or strips are in a carton box.
Conditions of supply:
KUSUM HEALTHCARE PVT LTD.
SP 289 (A), RIICO Industrial area, Chopanki, Bhiwadi, Dist. Alwar (Rajasthan), India.