General physic-chemical properties:white, circular, biconvex enteric film coated tablets.
Drugs for disorders of the musculo-skeletal system. Enzymes. Code АТХ M09A B.
Serratiopeptidase is a proteolytic enzyme extracted from nonpathogenic intestinal bacteria Serratia E15.It has a fibrinolytic, anti-inflammatory and anti-edema activity. Except decreasing inflammatory process, serratiopeptidase reduces pain by blocking the release of pain-inducing amines from inflamed tissues.
Serratiopeptidase binds with blood alfa-2-macroglobulin in ratio 1:1, that masks its antigenicity, but it retains its enzyme activity. Then gradually it penetrates into exudate at the inflammation site and its level in blood is gradually decreased.
Serratiopeptidase directly reduces the capillaries dilatation and controls theirs penetrability via hydrolysis of bradykinin, histamine and serotonin. Serratiopeptidase also blocks plasmin inhibitors and therefore promotes plasmin fibrinolytic activity. Due to proteolysis of sputum structural proteins, it improves the rheological properties of mucus and facilitates the expectoration.
Enzyme activity of the preparation is 10 times higher than that of α-chemotrypsin. In the focus of chronic inflammation, serratiopeptidase helps reduce the level of inflammatory mediators and pain; it hydrolyses fibrin. It has no significant effect on living organism proteins, such as albumin and α- and γ-globulin.;
The preparation well penetrates into the sites of inflammation, lyses necrotized tissues and their disintegration products, eliminates hyperemia and enhances antibiotics penetration and activity. The preparation reduces viscosity of saliva and nasal discharge, thereby enhancing their extraction.
The preparation passes the stomach unchanged and is absorbed in the intestine. The drug is not inactivated by gastric juice. Maximal concentration in plasma is reached in 1 hour. Serratiopeptidase reaches the bloodstream in the enzyme active form; it is also excreted with the bile in active form, and is detected in urine in insignificant quantity.
Surgical diseases: sprain and rupture of ligaments, fractures and dislocations, edemas caused by plastic surgery;
Airways diseases: it reduces the sputum viscosity and facilitates its excretion from respiratory tracts;
ENT organs diseases: it facilitates excretion of accessory sinuses secretion.
Skin diseases:acute inflammatory dermatosis.
Diseases of the female reproductive organs and breasts: haematomas, stagnation in the mammary glands.
Hypersensitivity to Serratiopeptidase or other drugs components. Blood coagulation impairment.
Interaction with other medicinal products and other forms of interaction.
In concurrent usage with anticoagulants the preparation intensifies their activity (such combination should be used under careful medical supervision), accelerates penetration of antibiotics, nonsteroidal anti-inflammatory drugs into the inflamed tissues.
Special warnings and precautions for use.
Since the preparation influences bold coagulation, it should be used with caution in the following conditions:
threat of bleeding;
impaired blood clotting time;
severe liver disease;
severe kidney disease.
The drug contains lactose. If you have established intolerance to some sugars, consult your doctor before taking this drug.
Administration in pregnancy and lactation.
The preparation use during pregnancy and lactation periods is not recommended due to absence of clinical data.
Ability to influence on velocity reactions while driving a motor transport and operating other machines.
It does not influence.
Administration and Dosage.
The preparation is administered in adults, in dose of 1 tablet 2–3 times per day after meal.
Tablets should be swallowed without chewing, followed with 1 glass of water.
Maximal daily dose is 30 mg.
The dosage and duration of the treatment course depends on the character and dynamics of pathology and is determined individually by the physician.
The drug is not used in children due to the absence of clinical data.
Symptoms: nausea, vomiting, anorexia, epigastric discomfort, in some cases – bleeding and bleed streaks in sputum.